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Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 57-62 doi: 10.1007/s11684-015-0389-8

Abstract: as the cause of tumor formation and recurrence, indicating the importance of studying novel therapyUsing a rabbit tumor model with VX2 hepatic carcinoma, we found that MMC alone increased lung metastasesMoreover, in a VX2 xenograft model by immunocompromised mice, MMC alone enriched tumor-initiating cellsgenomic instability, but MMC combined with AET attenuated the extent of genomic instability in primary VX2tumor tissue.

Keywords： rabbit VX2 liver tumor     mitomycin C     AET     stem-like cancer cells     genomic instability    

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Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 288-293 doi: 10.1007/s11684-011-0127-9

Abstract: Haemorheological abnormalities have been described in diabetes mellitus, as well as in non-alcoholic fatty liverHowever, the relationship between the changes in liver fat content and haemorheology is unknown.correlation between haemorheological parameters and intrahepatic lipid content (IHLC) in patients with type 2IHLC was quantified using proton magnetic resonance spectroscopy ( H-MRS) scanning of the liver.In summary, haemorheological disorders are linked to non-alcoholic fatty liver in type 2 diabetes.

Keywords： diabetes mellitus     type 2     haemorheology     non-alcoholic fatty liver disease    

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Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its

Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 443-446 doi: 10.1007/s11684-009-0079-5

Abstract: This paper aims to evaluate the effects and the possible mechanisms of atorvastatin on tumor growth andmetastasis in a xenograft tumor model.kinase (ERK), c-Jun N-terminal Kinase (JNK), and the expression of cytochrome P450 (CYP) subtype CYP2J2However, atorvastatin did not alter the expression of CYP2J2 in tumor tissue.These effects were not dependent on down-regulation of CYP2J2 expression.

Keywords： atorvastatin     xenograft tumor     metastasis     CYP2J2    

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Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 100-107 doi: 10.1007/s11684-009-0013-x

Abstract: The expression of integrin-β1, tumor growth factor-β (TGF-β) and tissue inhibitor of metalloproteinaseLiver function and pathological sections of each group in different stages of hepatic fibrosis was tested

Keywords： liver fibrosis     integrin-β1     resveratrol     tumor growth factor-β     tissue inhibitor of metalloproteinase-1    

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Adenovirus-mediated tissue inhibitor of metalloproteinase-3 gene transfection inhibits rabbit intervertebral

Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 415-420 doi: 10.1007/s11684-009-0072-z

Abstract: adenovirus vector carrying tissue inhibitor of metalloproteinase-3 (RAdTIMP-3) against degeneration of rabbitMild or moderate rabbit lumbar disc degeneration model was constructed with the controllable axial loadingdevice by imposing 98N pressure at the discs for 2 weeks.group 1; 20μL of RAd66 (an empty adenovirus vector, 1.0×10OPU/mL) in group 2;RAdTIMP-3 can effectively protect the matrix of rabbit intervertebral disc against overloading-induced

Keywords： tissue inhibitor of metalloproteinase-3     intervertebral disc     rabbit     gene therapy    

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Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive

Frontiers of Medicine doi: 10.1007/s11684-023-0999-5

Abstract: Through bioinformatics predictions, we identified that GTF2I and FAT1 were downregulated in thyroid carcinomaFurther, Pearson’s correlation coefficient revealed a positive correlation between GTF2I expression andThe under-expression of GTF2I and FAT1 was validated in TC cell lines.MSC-EVs could shuttle GTF2I into TPC-1 cells, where GTF2I inhibited TC malignant phenotypes, EMT, andIn vivo experiments confirmed that silencing of GTF2I accelerated tumor growth in nude mice.

Keywords： thyroid carcinoma     mesenchymal stem cell     extracellular vesicle     GTF2I     FAT1     CDK4    

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Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 1-7 doi: 10.1007/s11684-010-0105-7

Abstract:

Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques becauseSplit liver transplantation provides chances to two or even more recipients when only one liver graftBefore surgery, a series of donor evaluations—including anatomical, liver volume, and liver functionAt different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver

Keywords： partial liver transplantation     reduced-size liver transplantation     split liver transplantation     living donorliver transplantation    

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Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 784-798 doi: 10.1007/s11684-021-0911-0

Abstract: chemical interference approaches revealed that the loss of GNAQ/11 palmitoylation substantially affected tumorFurthermore, the palmitoylation inhibitor, 2-bromopalmitate, also specifically disrupted Gαq/11 downstream signaling by interfering with the MAPK pathway and BCL2 survival pathway/i>-mutant UM cells and showed a notable synergistic effect when applied in combination with the BCL2

Keywords： uveal melanoma     mutant GNAQ/11     palmitoylation     BCL2     combination target therapy    

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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract: γδ T cells are enriched in the liver and exhibit liver-specific features.fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regenerationWe believe that determining the properties and functions of γδ T cells in liver diseasesenhances our understanding of the pathogenesis of liver diseases and is useful for the design of novelγδ T cell-based therapeutic regimens for liver diseases.

Keywords： γδT cells     liver infection     non-alcoholic fatty liver disease     autoimmune hepatitis     liver fibrosis and cirrhosis     liver cancer     liver regeneration    

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Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 104-111 doi: 10.1007/s11684-017-0568-x

Abstract: effect of Rdh13 on liver injury induced by carbon tetrachloride (CCl ).under regular culture, the mice displayed an attenuated response to CCl -induced liver injury.expression levels of thyroid hormone-inducible nuclear protein 14 (Spot14) and cytochrome P450 (Cyp2e1) in the liver, especially after CCl treatment for 48 h.These data suggested that the alleviated liver damage induced by CCl in mice was caused by Cyp2e1

Keywords： retinol dehydrogenase 13     carbon tetrachloride     acute liver injury     Cyp2e1     Spot14    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the livernatural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liverdiseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma.and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholicliver disease     nonalcoholic fatty liver disease     hepatocellular carcinoma    

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract:

The liver has been characterized as a frontline lymphoid organ with complex immunological featuressuch as liver immunity and liver tolerance.Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infectionThe liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypicNK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infected

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins

Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 231-241 doi: 10.1007/s11684-013-0253-7

Abstract: PcG proteins assemble into polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2Last but not least, we will consider the therapeutic potential of targeting enhancer of zeste homolog 2(EZH2) as a possible treatment for HCC.

Keywords： liver cancer     epigenetics     histone modifications     polycomb group proteins     enhancer of zeste homolog 2 (EZH2    

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The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 495-505 doi: 10.1007/s11684-020-0790-9

Abstract: explore the effect and mechanisms of the treatment plan of “traditional Chinese medicine (TCM) regulating liverA total of 457 patients with HBV-related liver failure were retrospectively collected.In addition, there were significant differences in the expression of several cytokines related to liverRLR treatment can decrease jaundice, improve liver function, and significantly reduce the mortality inpatients with HBV-related liver failure.

Keywords： hepatitis B virus-related liver failure     traditional Chinese medicine     liver regeneration     liver regeneration    

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Title Author Date Type Operation

Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Journal Article

Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Journal Article

Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its

Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,

Journal Article

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Journal Article

Adenovirus-mediated tissue inhibitor of metalloproteinase-3 gene transfection inhibits rabbit intervertebral

Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,

Journal Article

Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive

Journal Article

Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Journal Article

Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Journal Article

γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Journal Article

Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins

Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong

Journal Article

The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Journal Article